"Inflammaging" is a term that refers to chronic, low-grade inflammation, which tends to increase with age. It is a combination of the words "inflammation" and "aging." Inflammation is a natural and necessary part of the immune response to injury or infection. However, chronic inflammation over an extended period can contribute to various age-related diseases and conditions.

"Inflammaging" describes the slow and progressive increase in systemic inflammation in the body, associated with the aging process. It is considered a driving force behind various age-related diseases, such as cardiovascular disease, diabetes, Alzheimer's disease, osteoporosis, and cancer.

causes

Inflammaging is triggered by a combination of age-related changes in the immune system (such as decreased immune regulation) and prolonged or chronic stressors (such as environmental factors, lifestyle, and chronic infections):

1. Accumulation of senescent cells: Senescent cells are cells that have reached a state of irreversible cell cycle arrest. While senescence can be a protective mechanism to prevent the growth of damaged cells, the accumulation of senescent cells is associated with increased inflammation.
2. Immune system dysregulation: With age, the immune system can become dysregulated, leading to a state of chronic, low-grade inflammation. The immune system may become less effective at distinguishing between harmful and harmless stimuli.
3. Changes in the gut microbiota: The composition of the gut microbiota (microorganisms in the digestive tract) can change with age. Imbalances in the gut microbiota have been associated with increased inflammation.
4. Cellular damage and DNA instability: Cellular damage and DNA instability, which are part of the aging process, can trigger inflammatory responses. This includes damage from oxidative stress and other cellular stressors.
5. Mitochondrial dysfunction: Disorders in the mitochondria, the energy-producing organelles within cells, can lead to an increased production of reactive oxygen species (ROS) and contribute to inflammation.
6. Environmental pollution: Chronic exposure to environmental factors such as pollution, smoking, and other toxins can contribute to inflammation.
7. Inflammation of adipose tissue: Inflammation in adipose tissue, especially in visceral fat, can release pro-inflammatory molecules and contribute to systemic inflammation.

diagnosis

The diagnosis of inflammaging is complex and usually based on the detection of inflammatory markers in the blood. Typical biomarkers that are measured include:

• C-reactive protein (CRP)
• Interleukin-6 (IL-6)
• Tumor necrosis factor alpha (TNF-alpha)

These markers provide information about the presence and extent of systemic inflammation.

Inflammaging is associated with various age-related diseases, including cardiovascular disease, neurodegenerative diseases, diabetes, and cancer. Chronic inflammation can adversely affect tissue function and repair, thus contributing to the overall decline in physiological functions associated with aging.

Understanding the mechanisms and causes of inflammaging is crucial for developing strategies to mitigate its effects and potentially promote healthier aging. Lifestyle factors such as a balanced diet, regular physical activity, and avoiding smoking can help reduce inflammation and contribute to overall well-being.

Possible therapies at the NADlongevity Institute in Munich

The NADlongevity Institute in Munich could pursue various therapeutic approaches to treat inflammaging or minimize its effects. Possible therapies include:

1. Lifestyle interventions: Recommendations regarding diet , exercise and stress management aimed at reducing inflammation and improving overall well-being.
2. Dietary supplements: Use of dietary supplements that have anti-inflammatory properties, such as omega-3 fatty acids, curcumin and antioxidants.
3. Drug treatment: Targeted drug therapies to reduce inflammatory markers, including the use of non-steroidal anti-inflammatory drugs (NSAIDs) or biologics, depending on the individual diagnosis and the patient's needs.
4. Targeted therapies: Innovative treatments that target specific causes of inflammaging, such as modulating the immune system or improving cellular metabolism.
5. Regenerative medicine: The use of regenerative medicine procedures to improve the function of damaged tissue and reduce inflammatory processes.

Please note that the exact treatment options and methods depend on the individual patient's health condition and the specific services and expertise of the NADlongevity Institute. It is important to contact the institute directly for detailed information and personalized advice.